I.S. (Pronounced Aiesu in Japanese) is not your everyday manga. This manga strictly deals with cases of intersexuality. I.S. stands for Inter Sexuality.
If you don't know what intersexuality is, refer to Wikipedia : http://en.wikipedia.org/wiki/Intersexual
By no means, this is a perverted series. This manga deals with very serious issues with intersexuality people. The pain they go through, the troubles they confront, and ultimately their inability to reproduce and even find a partner who will accept them as they are - It's all there in a form of manga.
The drawing of this manga is modern. In fact, the style of the drawing is not much different from your everyday manga.
The series is consisted with cases, each deals with different people though some cases are much longer and more dramatic than others.
I realize this manga is not for everyone. However, if you can handle the truth, this series might be very refreshing and give you insight.
I dropped this project due to personal reasons, one of which was the author's inability to draw any kind of darkside of being "Aiesu". If one was to touch a sensitive subject like this, one must be able to reflect its darkside as well as its bright side. The author's inability to draw only light side..., it didn't feel right.
There is shadow because of light. The author refused to admit that there is shadow.